Drug interactions
Cyclosporine + Hydrochlorothiazide-olmesartan
Severity: Moderate
Cyclosporine and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may reduce renal function and cause electrolyte disturbances. Thiazides can cause hyponatremia and hyperuricemia, cyclosporine is nephrotoxic and can cause hyperkalemia, and olmesartan can further raise potassium and affect renal hemodynamics.
What this interaction means in plain words
Cyclosporine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on renal function, electrolytes and uric acid through combined pharmacodynamic actions.
What to do
Monitor serum creatinine, sodium, potassium and uric acid regularly. Reduce doses or change antihypertensive therapy if renal function worsens or electrolytes become abnormal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Cyclosporine with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Cyclosporine and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may reduce renal function and cause electrolyte disturbances. Thiazides can cause hyponatremia and hyperuricemia, cyclosporine is nephrotoxic and can cause hyperkalemia, and olmesartan can further raise potassium and affect renal hemodynamics.
How serious is the interaction between Cyclosporine and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, sodium, potassium and uric acid regularly. Reduce doses or change antihypertensive therapy if renal function worsens or electrolytes become abnormal.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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