Drug interactions
Cyclosporine + Metformin-repaglinide
Severity: Major
Cyclosporine and Metformin-repaglinide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine substantially increases repaglinide exposure, raising the risk of hypoglycemia. The effect is greater at low repaglinide doses and needs dose limitation.
What this interaction means in plain words
Cyclosporine and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 and OATP1B1-mediated hepatic uptake and metabolism of repaglinide by cyclosporine.
What to do
Limit the repaglinide daily dose and monitor blood glucose more often; consider an alternative antidiabetic agent if hypoglycemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Cyclosporine with Metformin-repaglinide?
MediHelp rates the interaction as major. Cyclosporine and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine substantially increases repaglinide exposure, raising the risk of hypoglycemia. The effect is greater at low repaglinide doses and needs dose limitation.
How serious is the interaction between Cyclosporine and Metformin-repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the repaglinide daily dose and monitor blood glucose more often; consider an alternative antidiabetic agent if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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