Drug interactions
Cyclosporine + Tenofovir disoproxil
Severity: Major
Cyclosporine and Tenofovir disoproxil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine causes dose-related renal vasoconstriction and tubular injury, and tenofovir disoproxil can cause proximal tubular toxicity. Together they increase the risk of kidney impairment.
What this interaction means in plain words
Cyclosporine and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity.
What to do
Avoid the combination where possible, e.g. use an alternative antiretroviral such as an abacavir-based regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporine and Tenofovir disoproxil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Frequently asked questions
Can I take Cyclosporine with Tenofovir disoproxil?
MediHelp rates the interaction as major. Cyclosporine and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine causes dose-related renal vasoconstriction and tubular injury, and tenofovir disoproxil can cause proximal tubular toxicity. Together they increase the risk of kidney impairment.
How serious is the interaction between Cyclosporine and Tenofovir disoproxil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, e.g. use an alternative antiretroviral such as an abacavir-based regimen.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
