Drug interactions
Cytarabine + Dichlorphenamide
Severity: Moderate
Cytarabine and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide lowers serum potassium and can cause metabolic acidosis. Cytarabine commonly causes nausea, vomiting and diarrhea, so electrolyte disturbance may worsen.
What this interaction means in plain words
Cytarabine and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cytarabine belongs to Oncology; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive potassium depletion from renal losses with carbonic anhydrase inhibition plus chemotherapy-related gastrointestinal losses.
What to do
Monitor serum potassium and bicarbonate regularly and replace potassium as needed. Take extra care in patients with vomiting or diarrhea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cytarabine
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Cytarabine with Dichlorphenamide?
MediHelp rates the interaction as moderate. Cytarabine and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide lowers serum potassium and can cause metabolic acidosis. Cytarabine commonly causes nausea, vomiting and diarrhea, so electrolyte disturbance may worsen.
How serious is the interaction between Cytarabine and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and replace potassium as needed. Take extra care in patients with vomiting or diarrhea.
What other medicines interact with Cytarabine?
MediHelp also lists interactions of Cytarabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Cytarabine page.
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