Drug interactions
Cytarabine + Influenza virus vaccine adjuvanted
Severity: Moderate
Cytarabine and Influenza virus vaccine adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytarabine-related immunosuppression may reduce the antibody response to an adjuvanted H5N1 influenza vaccine. Protection may be less than expected.
What this interaction means in plain words
Cytarabine and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic chemotherapy-induced immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate before chemotherapy or between cycles with recovered counts when feasible. Maintain other infection precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cytarabine
Frequently asked questions
Can I take Cytarabine with Influenza virus vaccine adjuvanted?
MediHelp rates the interaction as moderate. Cytarabine and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytarabine-related immunosuppression may reduce the antibody response to an adjuvanted H5N1 influenza vaccine. Protection may be less than expected.
How serious is the interaction between Cytarabine and Influenza virus vaccine adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before chemotherapy or between cycles with recovered counts when feasible. Maintain other infection precautions.
What other medicines interact with Cytarabine?
MediHelp also lists interactions of Cytarabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Cytarabine page.
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