Drug interactions
Cytarabine + Ofatumumab sc
Severity: Moderate
Cytarabine and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and cytarabine suppresses bone marrow, so using them together may increase the risk of serious infections. The combined effect may be prolonged because of the long duration of B-cell depletion.
What this interaction means in plain words
Cytarabine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and cytotoxic myelosuppression.
What to do
Monitor blood counts and for signs of infection, and consider delaying ofatumumab until chemotherapy-related immunosuppression has resolved. Treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cytarabine and Ofatumumab sc, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cytarabine
Frequently asked questions
Can I take Cytarabine with Ofatumumab sc?
MediHelp rates the interaction as moderate. Cytarabine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and cytarabine suppresses bone marrow, so using them together may increase the risk of serious infections. The combined effect may be prolonged because of the long duration of B-cell depletion.
How serious is the interaction between Cytarabine and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection, and consider delaying ofatumumab until chemotherapy-related immunosuppression has resolved. Treat infections promptly.
What other medicines interact with Cytarabine?
MediHelp also lists interactions of Cytarabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Cytarabine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
