Drug interactions
Cytarabine + Tobramycin inhaled
Severity: Minor
Cytarabine and Tobramycin inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled tobramycin has low systemic absorption, but some exposure occurs and aminoglycosides can cause kidney and inner ear toxicity. Combined with other potentially nephrotoxic or neurotoxic agents, risk may rise, especially with renal impairment.
What this interaction means in plain words
Cytarabine and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive nephrotoxicity and ototoxicity from systemic tobramycin exposure with cytotoxic therapy.
What to do
Monitor serum creatinine and watch for hearing or balance symptoms during combined use. Consider tobramycin serum levels in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cytarabine
Frequently asked questions
Can I take Cytarabine with Tobramycin inhaled?
MediHelp rates the interaction as minor. Cytarabine and Tobramycin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inhaled tobramycin has low systemic absorption, but some exposure occurs and aminoglycosides can cause kidney and inner ear toxicity. Combined with other potentially nephrotoxic or neurotoxic agents, risk may rise, especially with renal impairment.
How serious is the interaction between Cytarabine and Tobramycin inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and watch for hearing or balance symptoms during combined use. Consider tobramycin serum levels in renal impairment.
What other medicines interact with Cytarabine?
MediHelp also lists interactions of Cytarabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Cytarabine page.
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