Drug interactions
Dabigatran + Deferasirox
Severity: Moderate
Dabigatran and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause gastric irritation, ulceration and gastrointestinal bleeding. Combined with the anticoagulant dabigatran, the chance of a clinically significant GI bleed is increased.
What this interaction means in plain words
Dabigatran and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk: deferasirox-related GI mucosal injury combined with dabigatran's direct thrombin inhibition.
What to do
Monitor for signs of GI bleeding and check hemoglobin periodically. Consider gastroprotection and reassess the need for both agents if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Frequently asked questions
Can I take Dabigatran with Deferasirox?
MediHelp rates the interaction as moderate. Dabigatran and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can cause gastric irritation, ulceration and gastrointestinal bleeding. Combined with the anticoagulant dabigatran, the chance of a clinically significant GI bleed is increased.
How serious is the interaction between Dabigatran and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and check hemoglobin periodically. Consider gastroprotection and reassess the need for both agents if bleeding occurs.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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