Drug interactions
Dabigatran + Fenoprofen
Severity: Major
Dabigatran and Fenoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs raise the risk of bleeding in patients on dabigatran through platelet inhibition and gastrointestinal mucosal injury. Serious bleeding including gastrointestinal hemorrhage can occur.
What this interaction means in plain words
Dabigatran and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment: anticoagulant thrombin inhibition plus NSAID platelet dysfunction and mucosal damage.
What to do
Avoid concurrent NSAIDs where possible and use paracetamol for analgesia instead. If unavoidable, use the shortest course, consider gastroprotection and monitor for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Dabigatran with Fenoprofen?
MediHelp rates the interaction as major. Dabigatran and Fenoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs raise the risk of bleeding in patients on dabigatran through platelet inhibition and gastrointestinal mucosal injury. Serious bleeding including gastrointestinal hemorrhage can occur.
How serious is the interaction between Dabigatran and Fenoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAIDs where possible and use paracetamol for analgesia instead. If unavoidable, use the shortest course, consider gastroprotection and monitor for bleeding and renal function.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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