Drug interactions
Dabigatran + Fluorouracil
Severity: Moderate
Dabigatran and Fluorouracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil can cause thrombocytopenia and mucositis with gastrointestinal bleeding, and dabigatran is an oral anticoagulant. Combined use increases the risk of bleeding.
What this interaction means in plain words
Dabigatran and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia and mucosal injury plus anticoagulation.
What to do
Monitor platelet counts and renal function, and watch for bleeding; hold or adjust dabigatran when platelets fall substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluorouracil
Frequently asked questions
Can I take Dabigatran with Fluorouracil?
MediHelp rates the interaction as moderate. Dabigatran and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluorouracil can cause thrombocytopenia and mucositis with gastrointestinal bleeding, and dabigatran is an oral anticoagulant. Combined use increases the risk of bleeding.
How serious is the interaction between Dabigatran and Fluorouracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and renal function, and watch for bleeding; hold or adjust dabigatran when platelets fall substantially.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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