Drug interactions
Dabigatran + Propranolol
Severity: Moderate
Dabigatran and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol may modestly inhibit intestinal P-glycoprotein, which can raise exposure to dabigatran etexilate. Higher dabigatran levels increase bleeding risk, especially in patients with impaired renal function.
What this interaction means in plain words
Dabigatran and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak P-glycoprotein inhibition by propranolol reduces efflux of dabigatran etexilate and increases its absorption.
What to do
Monitor for bleeding and check renal function regularly. Follow dabigatran labeling on P-gp inhibitors in renal impairment and reduce or avoid dabigatran where the label advises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Dabigatran with Propranolol?
MediHelp rates the interaction as moderate. Dabigatran and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol may modestly inhibit intestinal P-glycoprotein, which can raise exposure to dabigatran etexilate. Higher dabigatran levels increase bleeding risk, especially in patients with impaired renal function.
How serious is the interaction between Dabigatran and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check renal function regularly. Follow dabigatran labeling on P-gp inhibitors in renal impairment and reduce or avoid dabigatran where the label advises.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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