Drug interactions
Dabigatran + Tenofovir disoproxil
Severity: Minor
Dabigatran and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is not a P-glycoprotein inducer and is not known to meaningfully change dabigatran exposure. The legacy claim of reduced dabigatran effect is not supported.
What this interaction means in plain words
Dabigatran and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; tenofovir is a P-gp substrate, not an inducer.
What to do
No dose change is needed; consider renal function when dosing dabigatran given tenofovir's potential nephrotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Dabigatran with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Dabigatran and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenofovir is not a P-glycoprotein inducer and is not known to meaningfully change dabigatran exposure. The legacy claim of reduced dabigatran effect is not supported.
How serious is the interaction between Dabigatran and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; consider renal function when dosing dabigatran given tenofovir's potential nephrotoxicity.
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