Drug interactions
Dabrafenib + Diltiazem
Severity: Moderate
Dabrafenib and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower diltiazem exposure, reducing its effect.
What this interaction means in plain words
Dabrafenib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Diltiazem belongs to Cardiovascular.
Why it happens
Dabrafenib induces CYP3A4, increasing diltiazem clearance.
What to do
Monitor blood pressure and heart rate and raise the diltiazem dose if needed, or choose an alternative agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Diltiazem?
MediHelp rates the interaction as moderate. Dabrafenib and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower diltiazem exposure, reducing its effect.
How serious is the interaction between Dabrafenib and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and raise the diltiazem dose if needed, or choose an alternative agent.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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