Drug interactions
Dabrafenib + Doxorubicin
Severity: Minor
Dabrafenib and Doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower exposure to CYP3A4 substrates. The effect on doxorubicin is likely small as CYP3A4 is a minor elimination route.
What this interaction means in plain words
Dabrafenib and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Doxorubicin belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, potentially increasing doxorubicin metabolism.
What to do
No routine adjustment is needed. Monitor for reduced efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Doxorubicin?
MediHelp rates the interaction as minor. Dabrafenib and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and may lower exposure to CYP3A4 substrates. The effect on doxorubicin is likely small as CYP3A4 is a minor elimination route.
How serious is the interaction between Dabrafenib and Doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for reduced efficacy.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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