Drug interactions
Dabrafenib + Ethosuximide
Severity: Moderate
Dabrafenib and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower ethosuximide concentrations. Reduced anti-absence seizure control may result.
What this interaction means in plain words
Dabrafenib and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Ethosuximide belongs to Central Nervous System.
Why it happens
Dabrafenib induces CYP3A4, increasing ethosuximide clearance.
What to do
Monitor seizure frequency and ethosuximide levels, and increase the dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ethosuximide?
MediHelp rates the interaction as moderate. Dabrafenib and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower ethosuximide concentrations. Reduced anti-absence seizure control may result.
How serious is the interaction between Dabrafenib and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and ethosuximide levels, and increase the dose if control worsens.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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