Drug interactions
Dabrafenib + Etoposide
Severity: Moderate
Dabrafenib and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may lower etoposide exposure, possibly reducing its efficacy.
What this interaction means in plain words
Dabrafenib and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Etoposide belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, accelerating etoposide metabolism.
What to do
Monitor clinical response to etoposide and consider whether an alternative is needed if efficacy falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporine + Etoposide Major
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Etoposide?
MediHelp rates the interaction as moderate. Dabrafenib and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may lower etoposide exposure, possibly reducing its efficacy.
How serious is the interaction between Dabrafenib and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to etoposide and consider whether an alternative is needed if efficacy falls.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.
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