Drug interactions
Dabrafenib + Fentanyl
Severity: Moderate
Dabrafenib and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can lower fentanyl exposure, leading to reduced analgesia or opioid withdrawal in dependent patients. When dabrafenib is stopped, fentanyl levels can rise again and cause excess sedation or respiratory depression.
What this interaction means in plain words
Dabrafenib and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Fentanyl belongs to Musculoskeletal.
Why it happens
Dabrafenib induces CYP3A4, increasing the metabolism of fentanyl.
What to do
Monitor pain control and withdrawal symptoms and titrate fentanyl as needed while dabrafenib is taken. Reduce the fentanyl dose and monitor for respiratory depression if dabrafenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Fentanyl, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Fentanyl?
MediHelp rates the interaction as moderate. Dabrafenib and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can lower fentanyl exposure, leading to reduced analgesia or opioid withdrawal in dependent patients. When dabrafenib is stopped, fentanyl levels can rise again and cause excess sedation or respiratory depression.
How serious is the interaction between Dabrafenib and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and withdrawal symptoms and titrate fentanyl as needed while dabrafenib is taken. Reduce the fentanyl dose and monitor for respiratory depression if dabrafenib is discontinued.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
