Drug interactions
Dabrafenib + Isoniazid
Severity: Moderate
Dabrafenib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 and modestly increase dabrafenib exposure, raising the risk of pyrexia, skin toxicity and hyperglycemia.
What this interaction means in plain words
Dabrafenib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, which contributes to dabrafenib metabolism.
What to do
Monitor for pyrexia, rash and blood glucose, and reduce the dabrafenib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Isoniazid?
MediHelp rates the interaction as moderate. Dabrafenib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may inhibit CYP3A4 and modestly increase dabrafenib exposure, raising the risk of pyrexia, skin toxicity and hyperglycemia.
How serious is the interaction between Dabrafenib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pyrexia, rash and blood glucose, and reduce the dabrafenib dose if toxicity develops.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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