Drug interactions
Dabrafenib + Ketamine
Severity: Minor
Dabrafenib and Ketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2B6 and can lower exposure to drugs cleared by these enzymes. Ketamine may therefore have reduced effect, particularly with oral dosing.
What this interaction means in plain words
Dabrafenib and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Ketamine belongs to Central Nervous System.
Why it happens
Dabrafenib-mediated induction of CYP3A4 and CYP2B6 increasing ketamine metabolism.
What to do
Monitor clinical response to ketamine and titrate the dose upward as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ketamine?
MediHelp rates the interaction as minor. Dabrafenib and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and CYP2B6 and can lower exposure to drugs cleared by these enzymes. Ketamine may therefore have reduced effect, particularly with oral dosing.
How serious is the interaction between Dabrafenib and Ketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to ketamine and titrate the dose upward as needed.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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