Drug interactions
Dabrafenib + Lansoprazole
Severity: Moderate
Dabrafenib and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib capsules dissolve less well at higher gastric pH, so a proton pump inhibitor may lower dabrafenib absorption and potentially reduce antitumor efficacy. Dabrafenib also induces CYP3A4, which may modestly lower lansoprazole exposure.
What this interaction means in plain words
Dabrafenib and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH reduces dabrafenib solubility, and dabrafenib induces CYP3A4 and CYP2C19, increasing lansoprazole metabolism.
What to do
Monitor tumor response and consider whether acid suppression is still needed. If reflux symptoms worsen, titrate lansoprazole dose to symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Lansoprazole?
MediHelp rates the interaction as moderate. Dabrafenib and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib capsules dissolve less well at higher gastric pH, so a proton pump inhibitor may lower dabrafenib absorption and potentially reduce antitumor efficacy. Dabrafenib also induces CYP3A4, which may modestly lower lansoprazole exposure.
How serious is the interaction between Dabrafenib and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider whether acid suppression is still needed. If reflux symptoms worsen, titrate lansoprazole dose to symptoms.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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