Drug interactions
Dabrafenib + Metformin-sitagliptin
Severity: Moderate
Dabrafenib and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib can cause hyperglycemia, which may worsen control in patients with diabetes. Dabrafenib is also a CYP3A4 inducer but this does not materially affect metformin or sitagliptin.
What this interaction means in plain words
Dabrafenib and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Dabrafenib-associated hyperglycemia opposes antidiabetic effect; the mechanism is not fully established.
What to do
Monitor blood glucose at baseline and regularly during dabrafenib therapy, and adjust antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Dabrafenib and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib can cause hyperglycemia, which may worsen control in patients with diabetes. Dabrafenib is also a CYP3A4 inducer but this does not materially affect metformin or sitagliptin.
How serious is the interaction between Dabrafenib and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose at baseline and regularly during dabrafenib therapy, and adjust antidiabetic treatment as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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