Drug interactions
Dabrafenib + Metformin
Severity: Moderate
Dabrafenib and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib can cause hyperglycemia, particularly in patients with diabetes, which may worsen control on metformin. Glucose may need closer attention during therapy.
What this interaction means in plain words
Dabrafenib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Metformin belongs to Endocrine.
Why it happens
Dabrafenib-associated hyperglycemia opposes the effect of metformin; the mechanism is not fully established.
What to do
Monitor serum glucose at baseline and during dabrafenib treatment, and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Metformin?
MediHelp rates the interaction as moderate. Dabrafenib and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib can cause hyperglycemia, particularly in patients with diabetes, which may worsen control on metformin. Glucose may need closer attention during therapy.
How serious is the interaction between Dabrafenib and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum glucose at baseline and during dabrafenib treatment, and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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