Drug interactions
Dabrafenib + Pimozide
Severity: Moderate
Dabrafenib and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can lower pimozide concentrations, possibly reducing its antipsychotic or tic-suppressing effect. Dabrafenib itself can prolong the QT interval, so the combination needs attention.
What this interaction means in plain words
Dabrafenib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by dabrafenib increases the metabolism of pimozide.
What to do
Monitor clinical response to pimozide and adjust the dose if efficacy falls. Check the ECG for QTc changes, and reassess pimozide dosing if dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Pimozide?
MediHelp rates the interaction as moderate. Dabrafenib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can lower pimozide concentrations, possibly reducing its antipsychotic or tic-suppressing effect. Dabrafenib itself can prolong the QT interval, so the combination needs attention.
How serious is the interaction between Dabrafenib and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to pimozide and adjust the dose if efficacy falls. Check the ECG for QTc changes, and reassess pimozide dosing if dabrafenib is stopped.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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