Drug interactions
Dabrafenib + Sildenafil
Severity: Moderate
Dabrafenib and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can lower sildenafil exposure. This may lead to loss of efficacy, which matters most when sildenafil is used for pulmonary arterial hypertension.
What this interaction means in plain words
Dabrafenib and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Sildenafil belongs to Genitourinary.
Why it happens
Dabrafenib induces CYP3A4, increasing the hepatic and intestinal metabolism of sildenafil.
What to do
Monitor for reduced sildenafil response and titrate the dose as needed within labeled limits. Consider an alternative if the clinical effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Sildenafil?
MediHelp rates the interaction as moderate. Dabrafenib and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can lower sildenafil exposure. This may lead to loss of efficacy, which matters most when sildenafil is used for pulmonary arterial hypertension.
How serious is the interaction between Dabrafenib and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced sildenafil response and titrate the dose as needed within labeled limits. Consider an alternative if the clinical effect is lost.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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