Drug interactions
Dabrafenib + Theophylline
Severity: Moderate
Dabrafenib and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2C enzymes and may reduce theophylline concentrations. This could reduce bronchodilator efficacy, though CYP1A2 is the main theophylline pathway so the effect may be modest.
What this interaction means in plain words
Dabrafenib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Dabrafenib enzyme induction increases the hepatic metabolism of theophylline.
What to do
Measure theophylline serum levels after dabrafenib is started or stopped and increase the dose if levels are subtherapeutic. Re-check after dabrafenib is discontinued to avoid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Theophylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Theophylline?
MediHelp rates the interaction as moderate. Dabrafenib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2C enzymes and may reduce theophylline concentrations. This could reduce bronchodilator efficacy, though CYP1A2 is the main theophylline pathway so the effect may be modest.
How serious is the interaction between Dabrafenib and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure theophylline serum levels after dabrafenib is started or stopped and increase the dose if levels are subtherapeutic. Re-check after dabrafenib is discontinued to avoid toxicity.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
