Drug interactions
Dabrafenib + Tofacitinib
Severity: Moderate
Dabrafenib and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower tofacitinib concentrations, reducing efficacy. Potent CYP3A4 inducers such as rifampin reduce tofacitinib exposure substantially, and dabrafenib is a moderate inducer.
What this interaction means in plain words
Dabrafenib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by dabrafenib increases tofacitinib metabolism.
What to do
Monitor for loss of tofacitinib efficacy and consider an alternative if response declines. Reassess dosing if dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Tofacitinib?
MediHelp rates the interaction as moderate. Dabrafenib and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower tofacitinib concentrations, reducing efficacy. Potent CYP3A4 inducers such as rifampin reduce tofacitinib exposure substantially, and dabrafenib is a moderate inducer.
How serious is the interaction between Dabrafenib and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of tofacitinib efficacy and consider an alternative if response declines. Reassess dosing if dabrafenib is stopped.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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