Drug interactions
Dabrafenib + Ulipristal
Severity: Major
Dabrafenib and Ulipristal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower ulipristal concentrations, which can reduce contraceptive efficacy. Dabrafenib also reduces hormonal contraceptive effectiveness generally.
What this interaction means in plain words
Dabrafenib and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Dabrafenib induces CYP3A4, increasing ulipristal clearance.
What to do
Avoid ulipristal and use a copper intrauterine device for emergency contraception. Advise non-hormonal contraception during dabrafenib therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dabrafenib and Ulipristal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Ulipristal?
MediHelp rates the interaction as major. Dabrafenib and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4 and may lower ulipristal concentrations, which can reduce contraceptive efficacy. Dabrafenib also reduces hormonal contraceptive effectiveness generally.
How serious is the interaction between Dabrafenib and Ulipristal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ulipristal and use a copper intrauterine device for emergency contraception. Advise non-hormonal contraception during dabrafenib therapy.
What other medicines interact with Dabrafenib?
MediHelp also lists interactions of Dabrafenib with, for example, Abiraterone, Apalutamide, Carbamazepine. The full list is on the Dabrafenib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
