Drug interactions
Dabrafenib + Venlafaxine
Severity: Minor
Dabrafenib and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes, which may modestly lower venlafaxine exposure. Venlafaxine is cleared mainly by CYP2D6, so the effect is likely small, but reduced antidepressant effect is possible.
What this interaction means in plain words
Dabrafenib and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by dabrafenib increasing metabolism of venlafaxine.
What to do
Monitor for loss of antidepressant response and adjust the venlafaxine dose if clinically needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Venlafaxine?
MediHelp rates the interaction as minor. Dabrafenib and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and other enzymes, which may modestly lower venlafaxine exposure. Venlafaxine is cleared mainly by CYP2D6, so the effect is likely small, but reduced antidepressant effect is possible.
How serious is the interaction between Dabrafenib and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response and adjust the venlafaxine dose if clinically needed.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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