Drug interactions
Dabrafenib + Zolpidem
Severity: Moderate
Dabrafenib and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may reduce zolpidem concentrations, potentially lessening its hypnotic effect. The clinical impact is usually modest.
What this interaction means in plain words
Dabrafenib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Dabrafenib induction of CYP3A4 increases zolpidem metabolism.
What to do
Monitor for reduced hypnotic efficacy and adjust the zolpidem dose within labeled limits if needed, or consider an alternative hypnotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Zolpidem?
MediHelp rates the interaction as moderate. Dabrafenib and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may reduce zolpidem concentrations, potentially lessening its hypnotic effect. The clinical impact is usually modest.
How serious is the interaction between Dabrafenib and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic efficacy and adjust the zolpidem dose within labeled limits if needed, or consider an alternative hypnotic.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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