Drug interactions
Dacarbazine + Deferasirox
Severity: Moderate
Dacarbazine and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacarbazine is partly activated and cleared through CYP1A2, and deferasirox inhibits this enzyme. Exposure to dacarbazine may therefore rise, potentially increasing its myelosuppressive and gastrointestinal toxicity.
What this interaction means in plain words
Dacarbazine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacarbazine belongs to Oncology; Deferasirox belongs to Miscellaneous.
Why it happens
Deferasirox inhibits CYP1A2, reducing the metabolism of CYP1A2 substrates.
What to do
Monitor blood counts and watch for increased dacarbazine toxicity. Consider an alternative iron chelation approach if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dacarbazine
Other interactions of Deferasirox
Frequently asked questions
Can I take Dacarbazine with Deferasirox?
MediHelp rates the interaction as moderate. Dacarbazine and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacarbazine is partly activated and cleared through CYP1A2, and deferasirox inhibits this enzyme. Exposure to dacarbazine may therefore rise, potentially increasing its myelosuppressive and gastrointestinal toxicity.
How serious is the interaction between Dacarbazine and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for increased dacarbazine toxicity. Consider an alternative iron chelation approach if toxicity develops.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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