Drug interactions
Dacarbazine + Dengue vaccine
Severity: Major
Dacarbazine and Dengue vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The dengue vaccine is a live attenuated vaccine. In patients on cytotoxic chemotherapy the immune response may be reduced, and replication of the live virus may be less controlled, which is a safety concern.
What this interaction means in plain words
Dacarbazine and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine response and may permit uncontrolled replication of live attenuated virus.
What to do
Avoid live vaccination during chemotherapy and defer until immune recovery according to vaccine labeling and local guidance. Consider non-live vaccines where appropriate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dacarbazine
Frequently asked questions
Can I take Dacarbazine with Dengue vaccine?
MediHelp rates the interaction as major. Dacarbazine and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The dengue vaccine is a live attenuated vaccine. In patients on cytotoxic chemotherapy the immune response may be reduced, and replication of the live virus may be less controlled, which is a safety concern.
How serious is the interaction between Dacarbazine and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccination during chemotherapy and defer until immune recovery according to vaccine labeling and local guidance. Consider non-live vaccines where appropriate.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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