Drug interactions
Dacarbazine + Influenza virus vaccine trivalent adjuvanted
Severity: Moderate
Dacarbazine and Influenza virus vaccine trivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from dacarbazine may blunt the antibody response to inactivated influenza vaccine. The vaccine is still safe, and protection is generally worth pursuing in patients with cancer.
What this interaction means in plain words
Dacarbazine and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate ideally at least 2 weeks before chemotherapy, or between cycles when counts have recovered. Do not withhold the inactivated vaccine solely because of this interaction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dacarbazine
Frequently asked questions
Can I take Dacarbazine with Influenza virus vaccine trivalent adjuvanted?
MediHelp rates the interaction as moderate. Dacarbazine and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from dacarbazine may blunt the antibody response to inactivated influenza vaccine. The vaccine is still safe, and protection is generally worth pursuing in patients with cancer.
How serious is the interaction between Dacarbazine and Influenza virus vaccine trivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally at least 2 weeks before chemotherapy, or between cycles when counts have recovered. Do not withhold the inactivated vaccine solely because of this interaction.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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