Drug interactions
Dacarbazine + Meningococcal group b vaccine
Severity: Moderate
Dacarbazine and Meningococcal group b vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy can reduce the antibody response to the non-live meningococcal B vaccine. Patients may have weaker or shorter-lived protection.
What this interaction means in plain words
Dacarbazine and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immunogenicity.
What to do
Vaccinate before chemotherapy or during count recovery when possible. Do not delay needed vaccination in high-risk patients, and consider checking response or revaccinating after recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dacarbazine
Frequently asked questions
Can I take Dacarbazine with Meningococcal group b vaccine?
MediHelp rates the interaction as moderate. Dacarbazine and Meningococcal group b vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytotoxic chemotherapy can reduce the antibody response to the non-live meningococcal B vaccine. Patients may have weaker or shorter-lived protection.
How serious is the interaction between Dacarbazine and Meningococcal group b vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before chemotherapy or during count recovery when possible. Do not delay needed vaccination in high-risk patients, and consider checking response or revaccinating after recovery.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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