Drug interactions
Dacarbazine + Olaparib
Severity: Major
Dacarbazine and Olaparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and combining it with DNA-damaging chemotherapy can worsen and prolong these effects. The risk of serious cytopenias and infection is increased.
What this interaction means in plain words
Dacarbazine and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacarbazine belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from PARP inhibition and DNA alkylation.
What to do
Monitor blood counts closely, with baseline and regular checks, and interrupt or reduce doses for significant cytopenias. Dose reductions of one or both agents are often needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dacarbazine
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Dacarbazine with Olaparib?
MediHelp rates the interaction as major. Dacarbazine and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and combining it with DNA-damaging chemotherapy can worsen and prolong these effects. The risk of serious cytopenias and infection is increased.
How serious is the interaction between Dacarbazine and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely, with baseline and regular checks, and interrupt or reduce doses for significant cytopenias. Dose reductions of one or both agents are often needed.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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