Drug interactions
Dacarbazine + Tofacitinib
Severity: Major
Dacarbazine and Tofacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacarbazine can suppress bone marrow, and tofacitinib adds immunosuppression. Together they raise the risk of serious infections.
What this interaction means in plain words
Dacarbazine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacarbazine belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive myelosuppression and immunosuppression.
What to do
Avoid combined use where possible. If needed, monitor blood counts and infection and hold tofacitinib during neutropenia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Dacarbazine
Frequently asked questions
Can I take Dacarbazine with Tofacitinib?
MediHelp rates the interaction as major. Dacarbazine and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacarbazine can suppress bone marrow, and tofacitinib adds immunosuppression. Together they raise the risk of serious infections.
How serious is the interaction between Dacarbazine and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible. If needed, monitor blood counts and infection and hold tofacitinib during neutropenia.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
