Drug interactions
Danazol + Darifenacin
Severity: Moderate
Danazol and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a moderate CYP3A4 inhibitor and may raise darifenacin concentrations. Higher exposure can increase anticholinergic adverse effects such as dry mouth, constipation and blurred vision.
What this interaction means in plain words
Danazol and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of darifenacin.
What to do
Monitor for anticholinergic adverse effects and reduce the darifenacin dose if they are troublesome. Keep darifenacin at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danazol and Darifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Darifenacin
Frequently asked questions
Can I take Danazol with Darifenacin?
MediHelp rates the interaction as moderate. Danazol and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a moderate CYP3A4 inhibitor and may raise darifenacin concentrations. Higher exposure can increase anticholinergic adverse effects such as dry mouth, constipation and blurred vision.
How serious is the interaction between Danazol and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce the darifenacin dose if they are troublesome. Keep darifenacin at the lowest effective dose.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
