Drug interactions
Danazol + Doxorubicin
Severity: Moderate
Danazol and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may modestly raise doxorubicin exposure. The expected effect is increased myelosuppression or other anthracycline toxicity.
What this interaction means in plain words
Danazol and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, possibly reducing doxorubicin metabolism.
What to do
Monitor complete blood counts and signs of toxicity. Reduce the doxorubicin dose if excessive myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Frequently asked questions
Can I take Danazol with Doxorubicin?
MediHelp rates the interaction as moderate. Danazol and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and may modestly raise doxorubicin exposure. The expected effect is increased myelosuppression or other anthracycline toxicity.
How serious is the interaction between Danazol and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of toxicity. Reduce the doxorubicin dose if excessive myelosuppression occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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