Drug interactions
Danazol + Escitalopram
Severity: Minor
Danazol and Escitalopram: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may modestly raise escitalopram concentrations. Escitalopram is cleared by several pathways (CYP2C19, 3A4, 2D6), so the effect is usually small, though dose-related QT prolongation is a consideration.
What this interaction means in plain words
Danazol and Escitalopram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated escitalopram metabolism by danazol.
What to do
No routine dose change is needed. Monitor for increased adverse effects such as nausea, sedation or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Danazol with Escitalopram?
MediHelp rates the interaction as minor. Danazol and Escitalopram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak to moderate CYP3A4 inhibitor and may modestly raise escitalopram concentrations. Escitalopram is cleared by several pathways (CYP2C19, 3A4, 2D6), so the effect is usually small, though dose-related QT prolongation is a consideration.
How serious is the interaction between Danazol and Escitalopram?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for increased adverse effects such as nausea, sedation or palpitations.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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