Drug interactions
Danazol + Ethinyl estradiol-levonorgestrel
Severity: Minor
Danazol and Ethinyl estradiol-levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may modestly raise levels of ethinyl estradiol and levonorgestrel. Danazol is also an androgenic agent that opposes the hormonal intent of a contraceptive and is not appropriate in pregnancy. The pharmacokinetic effect is usually small.
What this interaction means in plain words
Danazol and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol weakly inhibits CYP3A4-mediated metabolism of the contraceptive steroids.
What to do
Monitor for estrogenic or progestogenic adverse effects such as breast tenderness, nausea or breakthrough bleeding. Ensure reliable contraception during danazol therapy because of its fetal risk.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danazol and Ethinyl estradiol-levonorgestrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Danazol with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as minor. Danazol and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may modestly raise levels of ethinyl estradiol and levonorgestrel. Danazol is also an androgenic agent that opposes the hormonal intent of a contraceptive and is not appropriate in pregnancy. The pharmacokinetic effect is usually small.
How serious is the interaction between Danazol and Ethinyl estradiol-levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic or progestogenic adverse effects such as breast tenderness, nausea or breakthrough bleeding. Ensure reliable contraception during danazol therapy because of its fetal risk.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
