Drug interactions
Danazol + Etoposide
Severity: Minor
Danazol and Etoposide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and may reduce the clearance of etoposide. This could increase etoposide exposure and the risk of myelosuppression and mucositis, though clinical data are lacking.
What this interaction means in plain words
Danazol and Etoposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of etoposide.
What to do
Monitor complete blood counts more closely during etoposide cycles given with danazol, and reduce the etoposide dose if marked cytopenias occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporine + Etoposide Major
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
Frequently asked questions
Can I take Danazol with Etoposide?
MediHelp rates the interaction as minor. Danazol and Etoposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak to moderate CYP3A4 inhibitor and may reduce the clearance of etoposide. This could increase etoposide exposure and the risk of myelosuppression and mucositis, though clinical data are lacking.
How serious is the interaction between Danazol and Etoposide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts more closely during etoposide cycles given with danazol, and reduce the etoposide dose if marked cytopenias occur.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.
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