Drug interactions
Danazol + Fentanyl
Severity: Moderate
Danazol and Fentanyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol weakly to moderately inhibits CYP3A4 and may increase fentanyl exposure. This can lead to enhanced opioid effects including sedation and respiratory depression.
What this interaction means in plain words
Danazol and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated fentanyl metabolism by danazol.
What to do
Monitor for sedation and respiratory depression and adjust the fentanyl dose accordingly, particularly when danazol is started or the dose changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Danazol with Fentanyl?
MediHelp rates the interaction as moderate. Danazol and Fentanyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol weakly to moderately inhibits CYP3A4 and may increase fentanyl exposure. This can lead to enhanced opioid effects including sedation and respiratory depression.
How serious is the interaction between Danazol and Fentanyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and adjust the fentanyl dose accordingly, particularly when danazol is started or the dose changed.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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