Drug interactions
Danazol + Glimepiride-pioglitazone
Severity: Moderate
Danazol and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol, an androgenic agent, can alter glucose metabolism and cause insulin resistance and glucose intolerance. This may change glycemic control in patients taking glimepiride and pioglitazone, so glucose levels may be less predictable.
What this interaction means in plain words
Danazol and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects of danazol alter insulin sensitivity and glucose tolerance; the net direction of effect varies between patients.
What to do
Monitor blood glucose closely when danazol is started or stopped. Adjust glimepiride or pioglitazone doses based on readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Frequently asked questions
Can I take Danazol with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Danazol and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol, an androgenic agent, can alter glucose metabolism and cause insulin resistance and glucose intolerance. This may change glycemic control in patients taking glimepiride and pioglitazone, so glucose levels may be less predictable.
How serious is the interaction between Danazol and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when danazol is started or stopped. Adjust glimepiride or pioglitazone doses based on readings.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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