Drug interactions
Danazol + Hydrocortisone
Severity: Minor
Danazol and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause fluid retention, so concurrent use may increase edema. Danazol may also inhibit CYP3A4 and raise corticosteroid exposure modestly.
What this interaction means in plain words
Danazol and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive sodium and fluid retention, with possible CYP3A4 inhibition by danazol reducing corticosteroid clearance.
What to do
Monitor weight, edema and blood pressure, and adjust the dose of either drug if fluid retention develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Danazol with Hydrocortisone?
MediHelp rates the interaction as minor. Danazol and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause fluid retention, so concurrent use may increase edema. Danazol may also inhibit CYP3A4 and raise corticosteroid exposure modestly.
How serious is the interaction between Danazol and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema and blood pressure, and adjust the dose of either drug if fluid retention develops.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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