Drug interactions
Danazol + Insulin detemir
Severity: Moderate
Danazol and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can cause insulin resistance and glucose intolerance, so insulin requirements may increase. Hyperglycemia is the more likely outcome.
What this interaction means in plain words
Danazol and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgenic effects of danazol alter insulin sensitivity and glucose metabolism, antagonizing insulin.
What to do
Monitor blood glucose when danazol is started or stopped and adjust insulin detemir dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Frequently asked questions
Can I take Danazol with Insulin detemir?
MediHelp rates the interaction as moderate. Danazol and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can cause insulin resistance and glucose intolerance, so insulin requirements may increase. Hyperglycemia is the more likely outcome.
How serious is the interaction between Danazol and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped and adjust insulin detemir dose accordingly.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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