Drug interactions
Danazol + Insulin lispro
Severity: Moderate
Danazol and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can cause insulin resistance and impair glucose tolerance, which may lead to hyperglycemia and a need for higher insulin doses. It can therefore weaken insulin control rather than enhance it.
What this interaction means in plain words
Danazol and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol's androgenic activity induces insulin resistance and altered glucose tolerance.
What to do
Monitor blood glucose when danazol is started, changed or stopped, and adjust insulin lispro dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Frequently asked questions
Can I take Danazol with Insulin lispro?
MediHelp rates the interaction as moderate. Danazol and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol can cause insulin resistance and impair glucose tolerance, which may lead to hyperglycemia and a need for higher insulin doses. It can therefore weaken insulin control rather than enhance it.
How serious is the interaction between Danazol and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started, changed or stopped, and adjust insulin lispro dose accordingly.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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