Drug interactions
Danazol + Ketamine
Severity: Minor
Danazol and Ketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and may modestly raise ketamine exposure. Clinically significant effects are unlikely with usual doses.
What this interaction means in plain words
Danazol and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4-mediated ketamine metabolism by danazol.
What to do
No dose adjustment is usually needed; titrate ketamine to effect and watch for prolonged sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Frequently asked questions
Can I take Danazol with Ketamine?
MediHelp rates the interaction as minor. Danazol and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and may modestly raise ketamine exposure. Clinically significant effects are unlikely with usual doses.
How serious is the interaction between Danazol and Ketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; titrate ketamine to effect and watch for prolonged sedation.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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