Drug interactions
Danazol + Metformin
Severity: Minor
Danazol and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol can cause insulin resistance and impaired glucose tolerance, so it is more likely to reduce than enhance metformin's effect. Glycemic control may worsen in patients with diabetes.
What this interaction means in plain words
Danazol and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Androgenic effects of danazol reduce insulin sensitivity, opposing metformin.
What to do
Monitor blood glucose when danazol is started or stopped. Adjust the antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin
Frequently asked questions
Can I take Danazol with Metformin?
MediHelp rates the interaction as minor. Danazol and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol can cause insulin resistance and impaired glucose tolerance, so it is more likely to reduce than enhance metformin's effect. Glycemic control may worsen in patients with diabetes.
How serious is the interaction between Danazol and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when danazol is started or stopped. Adjust the antidiabetic therapy as needed.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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