Drug interactions
Danazol + Pimozide
Severity: Major
Danazol and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4, which is a major pathway of pimozide metabolism. Increased pimozide exposure raises the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Danazol and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by danazol reduces pimozide metabolism.
What to do
Avoid the combination and use an alternative to danazol or pimozide. If unavoidable, monitor ECG and electrolytes and consider reducing the pimozide dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Danazol with Pimozide?
MediHelp rates the interaction as major. Danazol and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol inhibits CYP3A4, which is a major pathway of pimozide metabolism. Increased pimozide exposure raises the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Danazol and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative to danazol or pimozide. If unavoidable, monitor ECG and electrolytes and consider reducing the pimozide dose.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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