Drug interactions
Danazol + Theophylline
Severity: Moderate
Danazol and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol has been reported to increase serum theophylline concentrations. Toxicity such as tremor, palpitations, nausea or seizures may result.
What this interaction means in plain words
Danazol and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits hepatic metabolism of theophylline, probably via CYP enzyme inhibition.
What to do
Monitor theophylline serum levels and clinical signs of toxicity when danazol is started, and lower the theophylline dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Danazol with Theophylline?
MediHelp rates the interaction as moderate. Danazol and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol has been reported to increase serum theophylline concentrations. Toxicity such as tremor, palpitations, nausea or seizures may result.
How serious is the interaction between Danazol and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels and clinical signs of toxicity when danazol is started, and lower the theophylline dose as required.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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