Drug interactions
Danazol + Tofacitinib
Severity: Minor
Danazol and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may modestly raise tofacitinib concentrations. The clinical impact is likely small but could increase adverse effects.
What this interaction means in plain words
Danazol and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Danazol inhibits CYP3A4, reducing tofacitinib metabolism.
What to do
Monitor for tofacitinib adverse effects such as infection and cytopenias. Reduce the dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Danazol with Tofacitinib?
MediHelp rates the interaction as minor. Danazol and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a CYP3A4 inhibitor and may modestly raise tofacitinib concentrations. The clinical impact is likely small but could increase adverse effects.
How serious is the interaction between Danazol and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tofacitinib adverse effects such as infection and cytopenias. Reduce the dose if toxicity develops.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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